Jump to the main content block

HAYASHI Tamio


Award Honours:

2016 Yamada–Koga Prize(Japan Research Foundation for Optically Active Compounds)

2014 Negishi–Brown Lectures(Purdue University, USA)

2014 Robert Robinson Lectureship(Oxford University, UK)

2013 Foundation Lectureship Award 2013 in Organic Chemistry(Federation of Asian Chemical Societies)

2013 Boehringer-Ingelheim Lectureship(Boston College, USA)

2012 Aldrich Lecturer(The Scripps Research Institute)

2011 The Pfizer Lectureship(Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, Canada)

2011 AstraZeneca Lecture in Memory of Nils Löfgren(Stockholm University, Sweden)

2010 The Medal with Purple Ribbon (Shiju Hosho)(The Japanese Government)

2010 Khwarizmi International Award(IROST, Iran)

2008 Author C. Cope Scholar Awards(The American Chemical Society, USA)

2008 The Pfizer & Sigma Aldrich Lecture(University of Bristol, UK)

2007 The Ryoji Noyori Prize(The Society of Synthetic Organic Chemistry, Japan)

2007 Herbert C. Brown Lecturers(Purdue University, USA)

2007 Boehringer Ingelheim Lecturer(Université de Montréal, Canada)

2007 UC Irvine-Pfizer Symposium on Organic Synthesis(University of California, Irvine, USA)

2006 Morris S. Kharasch Visiting Professor(The University of Chicago, USA)

2005 The 20th Annual W. S. Johnson Symposium in Organic Chemistry(Stanford University, USA)

2005 Molecular Chirality Award(Japan)

2004 Thomson Scientific Research Front Award(Japan)

2004 Pfizer Symposium(Harvard University, USA)

2003 The Chemical Society of Japan Award(The Chemical Society of Japan)

2003 Oppolzer Lectures(Université de Genève, Switzerland)

2003 The Second Annual Merck/Caltech Symposium on Organic Synthesis(Caltech, USA)

2001-2002 Novartis Chemistry Lectureship(Novartis, Switzerland)

2000-2001 Novartis Lecturer in Organic Chemistry(Massachusetts Institute of Technology, USA)

1991 IBM Japan Science Prize(Japan)

1983 The Society of Synthetic Organic Chemistry, Japan, Award for Young Scientists(Japan)


Publications:

Selected Original papers in 2013-2019
(out of 473 publications, 37,166 total citations, H index = 101, Researcher ID)

  1. Synthesis of Arylacetaldehydes by Iridium-Catalyzed Arylation of Vinylene Carbonate with Arylboronic Acids. Wang, Z.; Xue, F.; Hayashi, T. Angew. Chem. Int. Ed2019, 58, 11054–11057.

  2. Enantioselective Synthesis of 3,3’-Diaryl-SPINOLS by Rh-Catalyzed Asymmetric Arylation–BF3-Promoted Spirocyclization Reactions.       Yin, L.; Xing, J.; Wang, Y.; Shen, Y.; Lu, T.; Hayashi, T. Dou, X. Angew. Chem. Int. Ed. 201958, 2474–2478.

  3. Addition of arylstannanes to alkynes giving ortho-alkenylarylstannanes catalysed cooperatively by a rhodium complex and zinc chloride.  Ming, J.; Shi, Q.; Hayashi, T. Chem. Sci. 2018, 9, 7700–7704.

  4. Asymmetric Synthesis of Axially Chiral 2-Aminobiaryls by Rhodium-Catalyzed Benzannulation of 1-Arylalkynes with 2-(Cyanomethyl)phenylboronates.  Xue, F.; Hayashi, T. Angew. Chem. Int. Ed. 2018, 57, 10368–10372.

  5. Rhodium-Catalyzed Enantioposition Selective Hydroarylation of Divinylphosphine Oxides with Arylboroxines. Wang, Z.; Hayashi, T. Angew. Chem. Int. Ed. 2018, 57, 1702–1706.

  6. Dynamic Kinetic Resolution in Rhodium-Catalyzed Asymmetric Arylation of Phospholene Oxides.  Lim, K. M.-H.; Hayashi, T. J. Am. Chem. Soc. 2017, 139, 8122–8125.

  7. Rhodium-Catalyzed Asymmetric Arylation/Defluorination of 1-(Trifluoromethyl)alkenes Forming Enantioenriched 1,1-Difluoroalkenes.  Huang, Y.; Hayashi, T. J. Am. Chem. Soc. 2016, 138, 12340–12343.

  8. Base Free Conditions for Rhodium-Catalyzed Asymmetric Arylation To Produce Stereochemically Labile α-Arylketones.  Dou, X.; Lu, Y.; Hayashi, T. Angew. Chem. Int. Ed. 2016, 55, 6739–6743.

  9. Asymmetric Conjugate Alkynylation of Cyclic α,β-Unsaturated Carbonyl Compounds with a Chiral Diene–Rhodium Catalyst.  Dou, X.; Huang, Y.; Hayashi, T. Angew. Chem. Int. Ed. 2016, 55, 1133–1137.

  10. Asymmetric Synthesis of Triarylmethanes by Rhodium-Catalyzed Enantioselective Arylation of Diarylmethylamines with Arylboroxines.  Huang, Y.; Hayashi, T. J. Am. Chem. Soc. 2015, 137, 7556–7559. 

  11. Rhodium-Catalyzed Asymmetric Arylation of Allyl Sulfones under the Conditions of Isomerization into Alkenyl Sulfones.  Lim, K. M.-H.; Hayashi, T. J. Am. Chem. Soc. 2015, 137, 3201–3204. 

  12. Nickel-Catalyzed Three-Component Domino Reactions of Aryl Grignard Reagents, Alkynes, and Aryl Halides Producing Tetrasubstituted Alkenes.  Xue, F.; Zhao, J.; Hor, T. S. A.; Hayashi, T. J. Am. Chem. Soc. 2015, 137, 3189–3192.  

  13. Tandem Catalysis of Amines Using Porous Graphene Oxide.  Su, C.; Tandiana, R.; Balapanuru, J.; Tang, W.; Pareek, K.; Nai, C. T.; Hayashi, T.; Loh, K. P. J. Am. Chem. Soc. 2015, 137, 685–690.

  14. High Performance of a Palladium-Phosphinooxazoline Catalyst in the Asymmetric Arylation of Cyclic N-Sulfonyl Ketimines.  Jiang, C.; Lu, Y.; Hayashi, T. Angew. Chem. Int. Ed. 2014, 53, 9936–9939.

  15. Asymmetric Synthesis of P-Stereogenic Diarylphosphinites by Palladium-Catalyzed Enantioselective Addition of Diarylphosphines to Benzoquinones.  Huang, Y.; Li, Y.; Leung, P. H.; Hayashi, T. J. Am. Chem. Soc. 2014, 136, 4865–4868.

  16. Single-Electron-Transfer-Induced Coupling of Arylzinc Reagents with Aryl and Alkenyl Halides.  Shirakawa, E.; Tamakuni, F.; Kusano, E.; Uchiyama, N.; Konagaya, W.; Watabe, R.; Hayashi, T. Angew. Chem. Int. Ed. 2014, 53, 521–525. 

  17. Enantioselective [3 + 2] Annulation via C–H Activation between Cyclic N-Acyl Ketimines and 1,3-Dienes Catalyzed by Iridium/Chiral Diene Complexes.  Nishimura, T.; Nagamoto, M.; Ebe, Y.; Hayashi, T. Chem. Sci. 2013, 4, 4499–4504.

  18. Rhodium-Catalyzed Asymmetric Hydroarylation of 3-Pyrrolines Giving 3-Arylpyrrolidines: Protonation as a Key Step.  So, C. M.; Kume, S.; Hayashi, T. J. Am. Chem. Soc. 2013, 135, 10990–10993.

  19. Iridium-Catalyzed [3 + 2] Annulation of Cyclic N-Sulfonyl Ketimines with 1,3-Dienes via C–H Activation.  Nishimura, T.; Ebe, Y.; Hayashi, T. J. Am. Chem. Soc. 2013, 135, 2092–2095.

  20. Hydroxorhodium/Chiral Diene Complexes as Effective Catalysts for the Asymmetric Arylation of 3-Aryl-3-hydroxyisoindolin-1-ones.  Nishimura, T.; Noishiki, A.; Ebe, Y.; Hayashi, T.  Angew. Chem. Int. Ed. 2013, 52, 1777–1780.

Selected Papers with High Citation (citation numbers are those at March 2019)

  1. tert-Butoxide-Mediated Arylation of Benzene with Aryl Halides in the Presence of a Catalytic 1,10-Phenanthroline Derivative.  Shirakawa, E.; Itoh, K.; Higashino, T.; Hayashi, T. J. Am. Chem. Soc. 2010, 132, 15537-15539. [cited 329]
  2. C2-Symmetric Bicyclo[2.2.2]octadienes as Chiral Ligands: Their High Performance in Rhodium-Catalyzed Asymmetric Arylation of N-Tosylarylimines.  Tokunaga, N.; Otomaru, Y.; Okamoto, K.;a Ueyama, K.; Shintani, R.; Hayashi, T. J. Am. Chem. Soc. 2004, 126, 13584–13585. [cited 306]
  3. A Chiral Chelating Diene as a New Type of Chiral Ligand for Transition Metal Catalysts:  Its Preparation and Use for the Rhodium-Catalyzed Asymmetric 1,4-Addition.  Hayashi, T.; Ueyama, K.; Tokunaga, N.; Yoshida, K. J. Am. Chem. Soc. 2003, 125, 11508–11509. [cited 362]
  4. Rhodium-Catalyzed Asymmetric 1,4-Addition and its Related Asymmetric Reactions: Hayashi, T; Yamasaki, K. Chem. Rev. 2003, 103, 2829–2844. [cited 1120]
  5. Catalytic Cycle of Rhodium-Catalyzed Asymmetric 1,4-Addition of Organoboronic Acids.  Arylrhodium, Oxa-π-allylrhodium, and Hydroxorhodium Intermediates.  Hayashi, T.; Takahashi, M.; Takaya, Y.; Ogasawara. M. J. Am. Chem. Soc. 2002, 124, 5052–5058. [cited 482]
  6. Chiral Monodentate Phosphine Ligand MOP for Transition-Metal-Catalyzed Asymmetric Reactions.  Hayashi, T. Acc. Chem. Res. 2000, 33, 354-362. [cited 393]
  7. Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryl- and Alkenylboronic Acids to Enones.  Takaya, Y.; Ogasawara, M.; Hayashi, T.; Sakai, M.; Miyaura, N. J. Am. Chem. Soc. 1998, 120, 5579–5580. [cited 572]
  8. Asymmetric Synthesis Catalyzed by Chiral Ferrocenylphosphine-Transition-Metal Complexes.  8.  Palladium-Catalyzed Asymmetric Allylic Amination.  Hayashi, T.; Yamamoto, A.; Ito, Y.; Nishioka, E.; Miura, H.; Yanagi, K. J. Am. Chem. Soc. 1989, 111, 6301-6311. [cited 355]
  9. Catalytic Asymmetric Aldol Reaction: Reaction of Aldehydes with Isocyanoacetate Catalyzed by a Chiral Ferrocenylphosphine-Gold(I) Complex.  Ito, Y.; Sawamura, M.; Hayashi, T. J. Am. Chem. Soc. 1986, 108, 6405–6406. [cited 671]
  10. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II): An Effective Catalyst for Cross-Coupling of Secondary and Primary Alkyl Grignard and Alkylzinc Reagents with Organic Halides.  Hayashi, T.; Konishi, M.; Kobori, Y.; Kumada, M.; Higuchi, T.; Hirotsu, K. J. Am. Chem. Soc. 1984, 106, 158–163. [cited 758]
  11. Asymmetric Synthesis Catalyzed by Chiral Ferrocenylphosphine-Transition Metal Complexes.  I.  Preparation of Chiral Ferrocenylphosphines.  Hayashi, T.; Mise, T.; Fukushima, M.; Kagotani, M.; Nagashima, N.; Hamada, Y.; Matsumoto, A.; Kawakami, S.; Konishi, M.; Yamamoto, K.; Kumada, M. Bull. Chem. Soc. Jpn. 1980, 53, 1138–1151. [cited 490]

 

Click Num: