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Department of Chemistry
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Chun-Cheng Lin

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Education

PhD, The Scripps Research Institute (1997)
MS, National Taiwan University (1989)
BS, National Tsing Hua University (1987)

 

Professional Experience
2018 ~ 2021 Professor of NTHU & Chairman
2006 ~ Professor of NTHU
2003 ~ 2006 Academic Sinica Associate Research Fellow
1998 ~ 2003 Academic Sinica Assistant Research Fellow
1997 ~ 1998 Postdoctoral Research, The Scripps Research Institute

Research Interest

1. Development of new methods for the synthesis of complex carbohydrate 
antigens.
2. Application of functionalized nanoparticle in glycobiology
3. Study of carbohydrate-protein interaction
4. Fabrication of biomolecule microarray

Publications
  1. Hsin-Kai Tseng, Hung-Kai Wang, Chun-Yen Wu, Chi-Kung Ni, and Chun-Cheng Lin* Exploring Regioselective Fucosylation Catalyzed by Bacterial Glycosyltransferases through Substrate Promiscuity and Acceptor-Mediated Glycosylation. ACS Catal. 2023, 13, 16, 10661–10671.
  2. Hsiao, H.-Y.;Chen, M.-L.; Wu, H.-T.; Huang, L.-D.; Chien, W.-T.; Yu, C.-C.; Jan, F.-D.; Sahabuddin, Sk; Chang, T.-C.; Lin, C.-C.*“Fabrication of Carbohydrate Microarrays through Boronate Formation”Chem. Comm.2011, 47, 1187-1189.
  3. Huang, L.-D.; Lin, H.-J.;Huang, P.-H.;Hsiao, W.-C.;Reddy, L. V. R.; Fu, S.-L.;* Lin, C.-C.*“Synthesis of serine-based glycolipids as potential TLR4 activators”Org. Biomol. Chem. 2011, 9, 2492-2504.
  4. Chen, C.-C.; Hsu, Wei Hsu; Hwang, K.-C.; Hwu, J. R.; Lin, C.-C.; Horng, J.-C.* “Contributions of cation–p interactions to the collagen triple helix stability”Archives of Biochem. Biophys. 2011, 508, 46–53.
  5. Wu, H.-T.; Hsu, C.-C.; Tsai,C.-F.; Lin,P.-C.; Lin, C.-C.*; Chen Y-J.*“Nanoprobe-based Immobilized Metal Affinity Chromatography for Sensitive and Complementary Enrichment of Multiply Phosphorylated Peptides”J. Proteomic Res. 2011, ASAP
  6. Tseng, M.-C.; Obena, R.; Lu, Y.-W.; Lin, P.-C.; Lin, P.-Y.; Yen, Y.-S.; Lin, J.-T.; Huang, L.-D.; Lu, K.-L.; Lai, L.-L.; Lin, C.-C.;* Chen, Y.-J.* “Dihydrobenzoic Acid Modified Nanoparticle as a MALDI-TOF MS Matrix for Soft Ionization and Structure Determination of Small Molecules with Diverse Structures”J. Am. Soc. Mass Spect. 2010, 21, 1930-1939.
  7. Ho, J.-a. A.;* Hsu, W.-L.; Liao, W.-C.; Chiu, J.-K.; Chen, M.-L.; Chang, H.-C.;Lin, C.-C.“Ultrasensitive Electrochemical Detection of Biotin Using Electrically Addressable Site-Oriented Antibody Immobilization Approach via Aminophenyl Boronic Acid”Biosensors and Bioelectronics 2010, 26, 021–1027
  8. Sahabuddin, Sk; Chang, T.-C.; Lin, C.-C.;Jan, F.-D.;Hsiao, H.-Y.; Huang, K.-T.;Chen, J.-H.;  Horng, J.-C.;Ho, J.-a. A.; Lin, C.-C.*“Synthesis of N-Modified sTn Analogs and Evaluation of Their Immunogenicities by Microarray-Based Immunoassay”Tetrahedron 2010,66, 7510-7519.
  9. Lin, C.-C.;Lin,N.-P.; Reddy, L. V. R.; Sahabuddin, Sk; Huang, L.-D.; Hwang, K. C.; Lin, C.-C.*“5-N,4-O-Carbonyl-7,8,9-tri-O-chloroacetyl-protected sialyl donor for the stereoselective synthesis of α-(2®9)-tetrasialic acid”J. Org. Chem. 75, 4921-4928. (Selected as the Featured Article)2010,
  10. Lai, C.-H.; Lin, C.-Y.; Wu, H.-T.; Chan, H.-S.; Chuang, Y.-J.; Chen, C.-T.; Lin, C.-C.*“Galactose encapsulated multifunctional nanoparticle for HepG2 cell internalization”Adv. Funct. Mater. 2010, 20, 3948-3958.
  11. Chen,J.-C.; Uang,B.-J.; Lyu, P.-C.; Chang, J.-Y.; Liu,K.-J.; Kuo, C.-C.; Hsieh, H.-P.; Wang, H.-C.; Cheng,C.-S.; Chang, Y.-H.; Chang, M. D.-T.;* Chang, W. W.-S.;* Lin, C.-C.*“Design and Synthesis of α-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis”J. Med. Chem. 2010, 53, 4545–4549.
  12. Chang, I.-P.; Hwang, K.-C.;* Ho, J. A.; Lin, C.-C.; Hwu, R. J.-R.; Horng, J.-C.“Facile Surface Functionalization of Nanodiamonds” Langmuir 2010, 26, 3685-3689
  13. Hwu, J.-R.;* Huang, J. J.-T.; Tsai, F.-Y.; Tsay, S.-C.; Hsu, M.-H.; Hwang, K.-C.; Horng, J.-C.; Ho, J. A.; Lin, C.-C.  “Photochemical Activities of N-Nitroso Carboxamides and Sulfoximides and Their Application to DNA Cleavage”Chemistry--A European Journal 2009, 15, 8742-8750.
  14. Lin, P.-C.;Chen,S.-H.; Wang, K.-Y.;Chen, M.-L.; Adak, A. K.;Hwu, J.-R. R. Chen, Y.-J.;* Lin, C.-C.*“Fabrication of Oriented Antibody-Conjugated Magnetic Nanoprobes and Their ImmunoaffinityApplication”Anal. Chem. 2009, 81, 8774-8782.
  15. Chang, S.-S.; Lin, C.-C.; Li, Y.-K.; Mong, K.-K. T.* “A straightforward -selective aromatic glycosylation and its application for stereospecific synthesis of 4-methylumbelliferyl -T-antigen” Carbohydr. Res. 2009, 344, 432-438.
  16. Ho, J.-a A.; Chiu, J.-K.; Hong, J.-C.; Lin, C.-C.; Hwang, K.-C.; Hwu, J.-R. R.* “Gold-nanostructured immunosensor for the electrochemical sensing of biotin based on liposomal competitive assay”J. Nanoscience and Nanotechnology 2009, 9, 2324-2329.
  17. Lin, P.-C.; Adak, A. K.; Ueng, S.-H.; Huang, L.-D.; Huang, K.-T.; Hwu, J.-R. R.; Lin, C.-C.*“DAST-Mediated Regioselective Anomeric Group Migration in Saccharides”J. Org. Chem. 2009,74, 4041-4048. (Selected as the Featured Article)
  18. Lin, C.-C.; Adak, A. K.; Horng, J.-C.; Lin, C.-C.* “Phosphite-based Sialic Acid Donors in the Synthesis of (2®9) Oligosialic Acids”Tetrahedron 2009, 65, 4714-4725.
  19. Ho, C.-C.; Lee, L. Y.-L.; Huang, K.-T.; Lin, C.-C.; Ku, M.-y.; Yang,C.-C.; Chan, S. I.; Chen, R. P.-Y.*Tuning the conformational properties of the prion peptide”Proteins: Structure, Function, and Bioinformatics 2009, 76, 213-225.
  20. Liang, C.-F.; Yan, M.-C.; Chang, T.-C.; Lin, C.-C. "Synthesis of S-Linked α(2→9) Octasialic Acid via Exclusive α S-Glycosidic Bond Formation", J. Am. Chem. Soc. 2009, 131, 3138-3139
  21. Yu, C.-C.; Lin, P.-C.; Lin, C.-C. “Site-specific immobilization of CMP-sialic acid synthetase on magnetic nanoparticles and its use in the synthesis of CMP-sialic acid”,Chem. Commun. 2008, 1308–1310.
  22. Chien, Y.-Y.; Jan, M.-D.; Adak, A. K.; Tzeng, H.-C.; Lin, Y.-P.; Chen,Y.-J.; Wang, K.-T.; Chen, C.-T.; Chen, C.-C.; Lin, C.-C. “ Globotriose-Functionalized Gold Nanoparticles as Multivalent Probes for Shiga-like Toxin”, ChemBioChem 2008, 9, 1100 – 1109.
  23. Shih, P.-H.; Shiu, J.-Y.; Lin, P.-C.; Lin, C.-C.; Veres, T.; Chen, P.  “ On chip sorting of bacterial cells using sugar-encapsulated magnetic nanoparticles”, Journal  of Applied Physics  2008, 103, 07A316.
  24. Chen, M.-L.; Adak, A. K.; Yeh, N.-C.; Yang, W.-B.; Chuang, Y.-J.; Wong, C.-H.; Hwang, K.-C.; Hwu, J.-R. Reuben; Hsieh, S.-L.; Lin C.-C. “Fabrication of an Oriented Fc-Fused Lectin Microarray through Boronate Formation”, Angew. Chem. Int. Ed. 2008,47,  8627 –8630.
  25. Chen, C.-T.; Munot, Y. S.; Salunke, S. B.; Wang, Y.-C.; Lin, R.-K.; Lin, C.-C.; Chen,C.-C.; Liu, Y-H. “ A Triantennary Dendritic Galactoside-Capped Nanohybrid with a ZnS/CdSe Nanoparticle Core as a Hydrophilic, Fluorescent, Multivalent Probe for Metastatic Lung Cancer Cells”, Adv. Funct. Mater. 2008, 18, 527–540.
  26. Hsin, Y.-L.; Lin, C.-F.; Liang, Y.-C.; Hwang, K. C.; Horng, J.-C.; Ho, J.-A. A.; Lin, C.-C.; Hwu, J. R. “ Microwave Arcing Induced Formation and Growth Mechanisms of Core/Shell Metal/Carbon Nanoparticles in Organic Solutions”, Adv. Funct. Mater. 2008,18, 2048–2056.
  27. Wang, K.-Y.; Chuang, S.-A.; Lin, P.-C.;| Huang, L.-S.; Chen, S.-H.; Ouarda, S.; Pan, W.-H.; Lee, P.-Y.; Lin, C.-C.; Chen, Y.-J. “Multiplexed Immunoassay: Quantitation and Profiling of Serum Biomarkers Using Magnetic Nanoprobes and MALDI-TOF MS „, Anal. Chem. 2008, 80, 6159–6167.
  28. Ln, P.-C.;Adak,A. K.; Lin, C.-C.*“Fabrication and Applications of Glyco-nanomaterials” in The Molecular Immunology of Complex Carbohydrates-3, Kluwaer Academic/Plenum Publisher, Wu, A. M. Ed.; 2008, in pressed.
  29. Lin, P.-C.; Wu, H.-T.; Wang, K.-Y.; Chen, Y.-J.;* Lin, C.-C.*“Development and Application of Functionalized Nanoparticles on Mass Spectrometry for the Analysis of Target Biomolecules”科儀新知 2008第二十九卷第四期,66-77.
  30. Yan, M.-C.; Chen, Y.-N.; Wu, H.-T.; Lin, C.-C.; Chen, C.-T.; Lin, C.-C.“Removal of Acid Labile Protecting Groups on Carbohydrates Using Water-tolerant and Recoverable Vanadyl Triflate Catalyst”J. Org. Chem. 2007, 72, 299-302.
  31. Huang, L.-S.; Chien, Y.-Y.; Chen, S.-H.; Lin, P.-C.; Wang, K.-Y.; Chou, P.-H.;Lin, C.-C.; Chen, Y.-J. “Nanoprobe-based Affinity Mass Spectrometry for Cancer Marker Protein Profiling” In Nanomaterials for cancer diagnosis; Kumar, C. S. S. R. Eds., Wiley-VCH: New York, 2007; Vol. 7, p338-3763.
  32. Hung LC, Lin CC, Hung SK, et al. “A synthetic analog of alpha-galactosylceramide induces macrophage activation via the TLR4-signaling pathways” Biochemical Pharmacology, 2007, 73 (12): 1957-1970.
  33. Lin PC, Ueng SH, Yu SC, et al. “Surface modification of magnetic nanoparticle via Cu(I)-Catalyzed alkyne-azide [2+3] cycloaddition”  Organic Letters, 2007, 9(11): 2131-2134.
  34. Lin CC, Tseng MC, Su AK, et al., “Functionalized magnetic nanoparticles for small-molecule isolation, identification, and quantification “Analytical Chem., 2007,79 (9): 3401-3408.
  35. Lin CC, Teng TM, Odedra A, et al. “Gold-catalyzed deoxygenated cyclization of cis-2,4-dien-1-als with regioselective addition of two nucleophiles. One-pot synthesis of highly functionalized cyclopentene framework”  J. Amer. Chem. Soc., 2007, 129 (13): 3798
  36. Chiu, T.-C.; Huang, L.-S.; Lin, P.-C.; {C}{C}描述: Anchor{C}.; Lin, C.-C.; Chang, H.-T.*“Nanomaterial Based Affinity Matrix-Assisted Laser Desorption/Inonization Mass Spectrometry for Biomolecules and Pathogenic Bacteria”Recent Patents on Nanotechnology 2007, 1, 99-111.
  37. Chang, C.-W; Chen, Y.-N.; Adak, A. K.; Lin, K.-H.; Tzou, D.-L.; Lin, C.-C.Synthesis of Phytosphingosine using Olefin Cross-Metathesis: A Convenient Access to Chain-modified Phytosphingosines from D-Lyxose Tetrahedron 2007, 63, 4310-4318.
  38. Liang, F.-C.; Chen, R. P.-Y.; Lin, C.-C.; Huang, K.-T.; Chan, S. I.“Tuning the conformation properties of a peptide by glycosylation and phosphorylation”Biochem. Biophys. Res. Commun. 2006, 342, 482-488.
  39. Lin, P.-C.; Chou, P.-H.: Chen, S.-H.; Liao, H.-K.; Chen, Y.-J.; Lin, C.-C.“Ethylene Glycol-Protected Magnetic Nanoparticles for Multiplexed immunoassay in Human Plasma” Small 2006, 2, 485-489. (Selected as journal cover)
  40. Lin, P.-C.; Ueng, S.-H.; Tseng, M.-C.; Ko, J.-L.; Huang, K.-T.; Yu, S.-C.; Adak, A. K.; Chen, Y.-J.; Lin, C.-C.“Site-Specific Protein Modification via Copper(I)-Catalyzed 1,2,3-Triazole Formation and Its Implementation in Protein Microarray Fabrication” Angew. Chem. Int. Ed. Engl. 2006, 45, 4286-4290. (Selected as the Hot paper)
  41. Lin, C.-C.; Jan, M.-D.; Weng, S.-S.; Lin, C.-C.; Chen, C.-T.“O-Isopropylidenation of Carbohydrates Catalyzed by Vanadyl Triflate” Carbohydr. Res. 2006, 341, 1948-1953.
  42. Lin, C.-C.; Huang, L.-C.; Liang, P.-H.; Liu, C.-Y.; Lin, C.-C.“Large Scale Synthesis of Per-O-Acetylated Saccharides and Their Sequential Transformation to Glycosyl Bromides and Thioglycosides”J. Carbohydr. Chem. 2006, 25, 303-313.
  43. Huang K.-T., Wu B.-C., Lin C.-C., Luo, S.-C.; Chen, C.; Wong C.-H., Lin, C.-C.“Multi-enzyme One-pot Strategy for the Synthesis of Sialyl Lewis X-containing PSGL-1 Glycopeptide” Carbohydr. Res. 2006, 341, 2151-2155.
  44. Chen, Y.-J.; Chen, S.-H; Chien, Y.-Y.; Chang, Y.-W.; Liao, H.-K.; Chang, C.-Y.; Jan, M.-D.; Wang, K.-T.; Lin, C.-C. “A Nanoprobe-Based Affinity Mass Spectrometry Approach for Direct Target Protein Identification and Binding Epitope Mapping” ChemBioChem. 2005, 6, 1169-1173.
  45. Sarkar, T. K.; Hazra, A.; Gangopadhya, P.; Panda, N.; Slanina, Z.; Lin, C.-C.;Chen, H.-T “Synthesis of the Necine bases (±)-Macronecine and (±)-Supinidine via an Aza-ene Reaction and Allylsilane Induced Ring Closure” Tetrahedron 2005, 61,1155-1165.
  46. Hsieh, S.-Y.; Jan, M.-D.; Patkar, L. N.; Chen, C.-T.; Lin, C.-C. “Synthesis of PkTrisaccahride with a Carboxyl Functionality Linker” Carbohydr. Res. 2005, 340, 49-57.
  47. Fan, G.-T.; Pan, Y.-s.; Lu, K.-C.; Cheng, Y.-P.; Wong, C.-H.; Lin, W.-C.; Lin, C.-H.; Fang, J.-M.; Lin, C.-C.; “Synthesis of -Galactosyl Ceramide and the Related Glycolipids for Evaluation of Their Activities on Mouse Splenocytes” Tetrahedron 2005, 61, 1855-1862.
  48. Chen, C.-T.; Weng, S.-S.; Kao, J.-Q.; Lin, C.-C.; Jan, M.-D. “Stripping off water at ambient temperature: Direct atom-efficient acetal formation between aldehydes and diols catalyzed by water-tolerant and recoverable vanadyl triflate” Org. Lett.2005, 7, 3343-3346.
  49. Chou, P.-H.; Chen, S.-H; Liao, H.-K.; Lin, P.-C.; Her, G. R.; Lai, A. C.-Y.; Lin, C.-C.; Chen, Y.-J. “Nanoprobe-Based Affinity Mass Spectrometry for Selected Protein Profiling in Human Plasma” Anal. Chem. 2005, 77, 5990-5997.
  50. Lin, C.-C.; Lin, C.-C.; “N-Trifluoroacetyl Sialyl Phosphite Donors for the Synthesis of(2→9) Oligosialic Acids” Org. Lett. 2005, 7, 4169-4172.
  51. Chen, F.-Y.; Patkar, L. N.; Ueng, S.-H.; Lin, C.-C.; Lee, A. S.-Y. “Synthesis of -Amino Esters by Regioselective Amination of Allyl Bromides with Aryl and Alkyl Amines” SynLett. 2005, 2035-2038.
  52. Chen, M.-Y.; Patkar, L. N.;Lu, K.-C.; Lee, A. S.-Y.; Lin, C.-C. “Chmoselective deprotection of acid labile primary hydroxyl-protecting groups under CBr4-photoirradiation conditions” Tetrahedron 2004, 60, 11465-11475.
  53. Sarkar, T. K.; Basak, S.; Wainer, I.; Moaddel, R.; Yamaguchi, R.; Jozwiak, K; Chen, H.-T.; Lin, C.-C. “Coaxing a Pyridine Nucleus to Give up its Aromaticity: Synthesis and Pharmacological Characterization of Novel Conformationally Restricted Analogues of Nicotine and Anabasine” J. Med. Chem. 2004, 47, 6691-6701.
  54. Hsu, H.-Y.; Hua, K.-F.; Lin, C.-C.; Lin, C.-H.; Wong, C.-H. “Extract of Reishi Polysaccharides Induces Cytokine Expression via Toll-like Receptor 4-modulated Protein Kinase Signaling Pathways”J. Immunol. 2004, 173, 5989-5999.
  55. Lu, K.-C.; Hsieh, S.-Y.; Patkar, L. N.; Chen, C.-T.; Lin, C.-C.* “Simple and efficient Per-O-acetylation of Carbohydrates by Lithium Perchlorate Catalyst”Tetrahedron 2004, 60, 8967-8973.
  56. Chen, M.-Y.; Patkar, L. N.; Lin, C.-C. “Selective Oxidation of Glycosyl Sulfides to Sulfoxides Using Magnesium Monoperoxyphthalate and Microwave Irradiation” J. Org Chem. 2004, 69, 2884-2887.
  57. Lin, C.-C.; Pan, Y.-s.; Patkar, L. N.; Tzou, D.-L. M.; Subramanian, T.; Liu, H.-J.;Lin, C.-C. “A Versatile Approach towards the Synthesis of Novel Seven-Membered Iminocyclitols via Ring-Closing Metathesis – Dihydroxylation Reaction” Bioorg. Med. Chem. 2004, 12, 3259-3267.
  58. Lin, C.-C.; Hung, S.-M.; Lee, K.-C.; Cheng, C.-C. “Thermal Stabilization of DNA by a Disaccharide” J. Chin. Chem. Soc. 2004, 51, 655-658.
  59. Chen, M.-Y.; Patkar, L. N.; Jan, Mi-Dan.; Lee, A. S.-Y.; Lin, C.-C.“CBr4-photoirradiation protocol for chemoselective deprotection of acid labile primary hydroxyl protecting groups” Tetrahedron Lett. 2004, 45, 635-639.
  60. Chiu, H.-Y.; Tzou, D.-L. M. Patkar, L. N.; Lin, C.-C. “A Facile Synthesis of Phytosphingosine from Diisopropylidene-D-Mannofuranose” J. Org. Chem. 2003, 68, 5788-5791.
  61. Lin, C.-C.; Yeh,Y.-C.; Chen, G.-F.; Yang, C.-Y.; Chen, Y.-C.; Wu, Y.-C.; Chen, C.-C. “Quantitative Analysis of Multivalent Interactions of Carbohydrate Encapsulated Gold Nanoparticles with Concanavalin A” Chem. Comm. 2003, 2920-2921.
  62. Chen, M.-Y.; Patkar, L. N.; Chen, H.-T.; Lin, C.-C. “An efficient and selective method for preparing glycosyl sulfoxides by oxidizing glycosyl sulfides with OXONE or t-BuOOH on SiO2” Carbohydr. Res. 2003, 338, 1327-1332.
  63. Lin, C.-C.; Fan, G.-T.; Fang, J.-M. “A concise Route to Phyosphingosine from Lyxose” Tetrahedon Lett. 2003, 44, 5281-5283.
  64. Wang, Y-Y.; Khoo, K.-H.; Chen, S-T.; Lin, C.-C.; Wong, C.-H.; Lin, C.-H “Studies on the Immuno-modulating Antitumor Activities of Ganoderma lucidum (Reishi) Polysaccharides: Functional and Proteomic Analyses of a Fucose-containing Glycoprotein Responsible for the Activities” Bioorg. Med. Chem. 2002, 10, 1057-1062.
  65. Lin, C.-C.; Yeh, Y.-C.; Yang, C.-Y.; Chen, C.-L.; Chen, C.-F.; Chen, C.-C.; Wu, Y.-C. “Selective Binding of Mannose Encapsulated Gold Nanoparticles on Type 1 Pili in Escherichia coli” J. Am. Chem. Soc. 2002, 124, 3508-3509.
  66. Chen, M.-Y.; Lu, K.-C.; Lee, A. S.-Y.; Lin, C.-C. “Chemoselective deprotection of primary tert-butyldimethylsilyl ethers on carbohydrate molecules in the presence of secondary silyl” Tetrahedon Lett. 2002, 43, 2777-2780.
  67. Lu, K.-C.; Tseng, S.-Y; Lin, C.-C. “5-Azido neuraminic acid thioglycoside as sialylation donor” Carbohydr. Res. 2002, 337, 755-760.
  68. Chen, P.-Y.; Lin, C.-C.; Chang, Y.-T.; Lin, S.-C.; Chan, S. I. “One O-linked sugar can affect the coil-to- structural transition of the prion peptide” Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 12633-12638.
  69. Fan, G.-T.; Lee, C.-C.; Lin, C.-C.; Fang, J.-M. “Stereoselective Synthesis of Neu5Ac(2→5)Neu5Gc-the Building Block of Oligo/Poly(→5-OglycolylNeu5Gc2→) Chains in Sea Urchin Egg Cell Surface Glycoprotein”J. Org. Chem. 2002, 67, 7565-7568.
  70. Chang, Y.-P.; Chen, H.-T.; Lin, C.-C. “A convenient and high stereoselectivity approach for -galactosylation performed by galactopyranosyl dibenzyl phosphite with remote participating groups” Tetrahedon Lett. 2002, 43, 7721-7723.
  71. Yu, C.-S.; Niikura, K.; Lin, C.-C.; Wong, C.-H. “The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for -Glycosylation of Primary Hydroxyls” Angew. Chem. Int. Ed. Engl. 2001, 40, 2900-2903.
  72. Lin, C.-C.; Subramanian, T.; Hus, T.-S.; Fan, G.-T.; Lin, C.-C. “Synthesis of C-linked disaccharides via olefin cross-metathesis”,J. Chin. Chem. Soc. 2001, 48,55-58.
  73. Lin, C.-H.; Lin, C.-C. “Enzymatic and Chemical Approaches for the Synthesis of Sialyl Glycoconjugates” in The Molecular Immunology of Complex Carbohydrates-2, Kluwaer Academic/Plenum Publisher, Wu, A. M. Ed.; 2001, 215-230.
  74. Subramanian, T.; Lin, C.-C.; Lin, C.-C. “Synthesis of oxazolidinyl azacycles via ring-closing olefin metathesis : a practical entry to the synthesis of deoxy-azasugars and hydroxypyrrolizidines” Tetrahedon Lett. 2001, 42, 4079-4082.
  75. Lin, C.-C.; Hsu, T.-S.; Lu, K.-C.; Huang , I-T. “Synthesis of -D-Glucopyranosyl1→3)-1-thiol-glucosamine Disaccharide Derivative as Building Block for the Synthesis of Hyaluronic Acid”,J. Chin. Chem. Soc. 2000, 47, 921-928.
  76. Fan, G.-T.; Hus, T.-S; Lin, C.-C; Lin, C.-C. “Ring-closing olefin metathesis of prearranged C-allyl saccharides for the synthesis of C- butyl linked homo- and hetero-disaccharides”, Tetrahedon Lett. 2000, 41, 6593-6597.
  77. Chiu, Y.-J.; Lin, C.-C. “Carbohydrate Antigen and Vaccine” Chemistry 2000, 58,301-308. (Review in Chinese)
  78. Lin, C.-C.; Moris-Varas, F.; Weitz-Schmidt, G.; Wong, C.-H. “Synthesis of Sialyl Lewis X Mimetics as Selectins Inhibitors by Enzymatic Aldol Condesation Reactions”, Bioorg. Med. Chem. 1999, 7, 425-433.
  79. Wu, W.-G.; Pasternack, L.; Huang, D.-H.; Koeller, K. M.; Lin, C.-C.; Ositz, O.; Wong, C.-H. “Structural Study on O-Glycopeptides: Conformational Differences ofO -GlcNAc, O -LacNAc,O -Sialyl-LacNAc, and O -Sialyl-Lewis-X Petides of the Mucin Domain of MadCAM-1”, J. Am. Chem. Soc. 1999, 121, 2409-2417.
  80. Lin, C.-C.; Lin, C.-H.; Wong, C.-H. “Sialic Acid Aldolase-Catalyzed Condensation of Pyruvate and N-Substituted Mannosamine : A Useful Method for The Synthesis of N-Substituted Sialic Acids”, Tetrahydron Lett. 1997, 38, 2649-2652.
  81. S.-C. Hung; Lin, C.-C.; Wong, C.-H. “One-pot Synthesis of 1-Allyl and 1-Allenyl-6-O-acety-2,3,4,-tri-O-benzyl-α-D-glycosides from Methyl Tetra-O-benzyl-α-D-glycosides”, Tetrahydron Lett. 1997, 38, 5419-5422.
  82. Wong, C.-H.; Moris-Varas, F.; Hung, S.-C.; Marron, T. G.; Lin, C.-C.; Gong, K.W.; Weitz-Schmidt, G. “Small Molecules as Structural and Functional Mimics of Sialyl Lewis X in Selectin Inhibition : A Remarkable Enhancement of Inhibition by Additional Negative Charge and/or Hydrophobic Group”, J. Am. Chem. Soc. 1997,119, 8152-8158.
  83. Uchiyama, T.; Woltering, T. J.; Wong, W.; Lin, C.-C.; Kajimoto, T.; Takebayashi, M.; Weitz-Schmidt, G.; Asakura, T.; Noda, M.; Wong, C.-H. “Design an Synthesis of C-Linked Fucosides as Inhibitors of E-Selectin” Bioorg. Med. Chem. 1996, 4, 1149-1165.
  84. Wu, S.-H.; Shimazaki, M.; Lin, C.-C.; Qiao, L.; Moree, W. J.; Wong, C.-H “Synthesis of Fucopeptides as Sialyl Lewis X Mimetics”, Angew. Chem. Int. Ed. Engl. 1996, 35, 88-90.
  85. Lin, C.-C.; Shimazaki, M.; Heck, M.-P.; Aoki, S.; Wang, R.; Kimura, T.;  Ritzen, H; Takayama, S.; Wu, S.-H.; Weitz-Schmidt, G.; Wong, C.-H. “Synthesis of Sialyl Lewis X Mimetics and Related Structures Using the Glycosyl Phosphite Methodology and Evaluation of E-Selectin” J. Am. Chem.Soc. 1996, 118, 6826-6840.
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Patent
  1. Wong, Chi-Huey; Lin, Chun-Cheng; Lin, Chun-Hung; Chen, Shui-Tein; Khoo, Kay-Hooi; Wang, Yuan-Yuan“Fucose-containing polysaccharides and glycopeptides from Ganoderma lucidum (Reishi) as anti-tumor and immuno modulating agents”
  2. U.S. Patent No. 7,135,183Lin, Chun-Cheng; Chen, Chia-Chun; Wu, Yi-Chun“Carbohydrate encapsulated nanoparticles”U.S. Patent No. 7,695,738 B2

 

 

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