Chia Yen Liew

	Education
	PhD, National Taiwan University & Academia Sinica (2023) MS, University of Malaya (2016) BS, University of Malaya (2012)
	Professional Experience
	2026	Assistant Professor of NTHU
	2023 ~ 2026	Postdoctoral Research, California Institute of Technology
	2023	Postdoctoral Research, Academia Sinica
	2016 ~ 2018	Research Assistant, Academia Sinica


	Research Interests
	Glycan Structural Analysis Mass Spectrometry (LODES/MSⁿ) Glycoproteomics and Protein Quality Control
	Future Research Directions
	Development of advanced mass spectrometry methods for glycan structural analysis Structural and functional characterization of glycoRNA Structural glycomics of bacterial surface glycans
	Research Summary & Vision
	Glycans are among the most structurally complex and biologically important biomolecules, playing critical roles in processes such as cell–cell communication, protein folding, immune recognition, and host–pathogen interactions. Despite their significance, glycan structures remain difficult to characterize due to their high structural diversity and isomeric complexity. My research focuses on developing advanced mass spectrometry–based approaches for de novo, isomer-resolved glycan structural determination, enabling detailed analysis beyond current limitations. By establishing integrated analytical workflows that incorporate glycan extraction, enrichment, and structural analysis, my work aims to uncover how glycan structures regulate biological function and contribute to disease. By treating glycan structure as the foundation for understanding biological function, I aim to establish a Glycomics and Mass Spectrometry research platform to advance interdisciplinary research and enable applications in diagnostics and biomedical science.
	Selected Publications
	Liew CY, Luo H, Chen J, Ni C. High Abundance of Unusual High Mannose N-Glycans Found in Beans. ACS Omega. (2024) Liew CY, Li WL, Ni CK. Structural determination of fructooligosaccharides and raffinose family oligosaccharides using logically derived sequence tandem mass spectrometry. Analyst. (2024) Liew CY, Chen JL, Lin YT, Luo HS, Hung AT, Magoling BJA, Nguan HS, Lai CP, Ni CK. Chromatograms and Mass Spectra of High-Mannose and Paucimannose N-Glycans for Rapid Isomeric Identifications. J Proteome Res. (2024) Liew CY, Luo HS, Yang TY, Hung AT, Magoling BJA, Lai CP, Ni CK. Identification of the High Mannose N-Glycan Isomers Undescribed by Conventional Multicellular Eukaryotic Biosynthetic Pathways. Anal Chem. (2023)

Click Num: