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Horng, Jia-Cherng(Jason)

Title: Associate Professor                             Chinese Version

Education:

State Univ. of New York at Stony Brook(USA)(Ph.D.) (2004)
National Tsing Hua University(M.S.) (1994)
National Taiwan Normal University(B.S.) (1992)

Office: Chemistry Building R402
Phone number: +886-3-5715131 ext. 35635
E-mail: jchorng@mx.nthu.edu.tw
Web site: http://mx.nthu.edu.tw/~jchorng

Professional Experience:

2011 ~
2006 ~ 2011
2004 ~ 2006

Associate Professor of NTHU
Assistant Professor of NTHU
Postdoctoral Research Associate, University of Wisconsin Madison

Research Interest:

Peptide Chemistry, Design, and Structure, Protein Folding and Design


Publications:(After 2006)


  1. Y. J. Lin, C. H. Chang, and J. C. Horng*. The impact of 4-thiaproline on polyproline conformation. J. Phys. Chem. B 2014, 118, 10813-10820.
  2. Y. J. Lin and J. C. Horng*. Impacts of terminal (4R)-fluoroproline and (4S)-fluoroproline residues on polyproline conformation. Amino Acids 2014, 46, 2317-2324.
  3. H. C. Tang, Y. J. Lin, and J. C. Horng*. Modulating the folding stability and ligand binding affinity of Pin1 WW domain by proline ring puckering. Proteins 2014, 82, 67-76.
  4. C. C. Hong, C. P. Chen, J. C. Horng, and S. Y. Chen. Point-of care protein sensing platform based on immuno-like membrane with molecularly-aligned nanocavities. Biosens. Bioelectron. 2013, 50, 425-430.
  5. M. C. Lu, L. L. Chiu, L. Y. Chiu, C. Y. Lin, and J. C. Horng*. Highly selective and water-soluble peptidyl chemosensors for copper(II) and mercury(II) ions based on a β-hairpin structure. Anal. Methods 2013, 5, 1702-1707.
  6. W. Hsu, Y. L. Chen, and J. C. Horng*. Promoting self-assembly of collagen-related peptides into various higher-order structures by metal-histidine coordination. Langmuir 2012, 28, 3194-3199.
  7. Z. S. Lin, F. C. Lo, C. H. Li, C. H. Chen, W. N. Huang, I. J. Hsu, J. F. Lee, J. C. Horng, and W. F. Liaw. Peptide-bound dinitrosyliron complexes (DNICs) and neutral/reduced-form Roussin’s red esters (RREs/rRREs): understanding nitrosylation of [Fe-S] clusters leading to the formation of DNICs and RREs using a de novo design strategy. Inorg. Chem. 2011, 50, 10417-10431.
  8. C. C. Chen, W. Hsu, T. C. Kao, and J. C. Horng*. Self-assembly of short collagen-related peptides into fibrils via cation-p interactions. Biochemistry 2011, 50, 2381-2383.
  9. C. C. Chen, W. Hsu, K. C. Hwang, J. R. Hwu, C. C. Lin, and J. C. Horng*. Contribution of cation-p interactions to the collagen triple helix stability. Arch. Biochem. Biophys. 2011, 508, 46-53.
  10. Y. S. Chen, C. C. Chen, and J. C. Horng*. Thermodynamic and kinetic consequences of substituting glycine at different positions in a Pro-Hyp-Gly repeat collagen model peptide. Biopolymers (Peptide Science) 2011, 96, 60-68.
  11. T. Y. Zheng, Y. J. Lin, and J. C. Horng*. Thermodynamic consequences of incorporating 4-substituted proline derivatives into a small helical protein. Biochemistry 2010, 49, 4255-4263.
  12. Y. C. Chiang, Y. J. Lin, and J. C. Horng*. Stereoelectronic effects on the transition barrier of polyproline conformational interconversion. Protein Sci. 2009, 18, 1967-1977.
  13. Y. W. Chiang, T. Y. Zheng, C. J. Kao, and J. C. Horng. Determination of interspin distance distributions by CW-ESR is a single linear inverse problem. Biophys. J. 2009, 97, 930-936.
  14. J. H. Cho, S. Sato, J. C. Horng, B. Anil, and D. P. Raleigh. Electrostatic interactions in the denatured state ensemble: their effect upon protein folding and protein stability. Arch. Biochem. Biophys. 2008, 469, 20-28.
  15. J. C. Horng, F. W. Kotch, and R. T. Raines. Is glycine a surrogate for a D-amino acid in the collagen triple helix? Protein Sci. 2007, 16, 208-215.
  16. J. C. Horng, A. J. Hawk, Q. Zhao, E. S. Benedict, S. D. Burke, and R. T. Raines. Macrocyclic scaffold for the collagen triple helix. Org. Lett. 2006, 8, 4735-4738
  17. Y. Li, J. C. Horng and D. P. Raleigh. pH Dependent thermodynamic and amide exchange studies of the C-terminal domain of the ribosomal protein L9: implications for unfolded state structure. Biochemistry 2006, 45, 8499-8506.
  18. J. C. Horng and R.a T. Raines. Stereoelectronic effects on polyproline conformation. Protein Sci. 2006, 15, 74-83.
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