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Hwu, Reuben Jih-Ru

Title： Professor                                             Chinese Version

Education：

Ph.D. (1982), Stanford University, U.S.A.
B.S. in Chemistry (1976), National Taiwan University
Office： Chemistry Building R602
Phone number：
 		 +886-3-5725813
+886-3-5715131 ext 33412
E-mail： jrhwu@mx.nthu.edu.tw
   

Professional Experience：

2015 ~ 2018
1990 ~
2007 ~ 2010
2010 ~ 2012
 
1982 ~ 1991
1999 ~
2000 ~
2005 ~
2003 ~
1991 ~ 1993
2011 ~ 2013
2010 ~ 2015
2000 ~
2006 ~
2010 ~
2011 ~ 2015
2013 ~ 
2014 ~

National Chair Professor of Ministry of Education
Chair Professor and Professor of National Tsing Hua University
Dean, College of Science, National Central University
Director, Preparatory Office for College of Biomedical Science and Engineering,
National Central University
Associate and Assistant Professor of The Johns Hopkins University
Fellow of The Academy of Sciences for the Developing World
Fellow of International Union of Pure and Applied Chemistry
Fellow of The Royal Society of Chemistry
Fellow of Asian Federation for Medicinal Chemistry
President, Chinese American Chemical Society, U.S.A
President, Asian Federation of Medicinal Chemistry
Consortium Partner of FP7 SILVER Project, European Commission
Regional Editor, Mini-Reviews in Medicinal Chemistry
Editorial Advisory Board, Anti-Infective Agents in Medicinal Chemistry
Editorial Board Member, Journal of Chemistry and Chemical Engineering
Editorial Board Member, World Journal of Virology
Ex Officio, Editorial Advisory Board Member, Journal of Medicinal Chemistry
Editorial Advisory Board Member, European Journal of Medicinal Chemistry

Research Interest：

Bionano Sciences & Technology, Gene Therapy, Organic Synthesis and Reactions,
Silicon Chemistry, as well as Polymer Science

Research Topics：

1. Development of new drugs for anti-cancer,anti-virus,and anti-bacteria;
2. Synthesis of biologically active compounds and natural products;
3. Development of new synthetic methods and strategies;
4. Synthesis of novel nano-biomaterials and nano-polymerts;
5. Development of organosilicon reagents and new silicon reactions for "Green Chemistry;"
6. Establishment of the concept and utilization of "counterattack reagents;" and
7. Development of novel DNA-and RNA-cleaving agents.


Selected Publications：

  1. Hwu, J.-R.; Singha, R.; Hong, S.-C.; Chang, Y.-H.; Das, A.-R.; Vliegen, I.; De Clercq, E.; Neyts, J. “Synthesis of New Benzimidazole-Coumarin Conjugates as Anti-Hepatitis C Virus Agents,” Antiviral Res. 2008, 77, 157–162.
  2. Hwu, J. R.; Lin, Y. S.; Josephrajan, T.; Hsu, M.-H.; Cheng, F.-Y.; Yeh, C.-S.; Su, W.-C.; Shieh, D.-B. “Targeted Paclitaxel by Conjugation to Iron Oxide and Gold Nanoparticles,” J. Am. Chem. Soc. 2009, 131, 66–68.
  3. Hwu, J. R.; Huang, J.-T.; Tsai, F.-Y., Tsay, S.-C.; Hsu, M. H.; Hwang, K. C.; Horng, J.-C.; Ho, J.-a. A. Lin C.-C. “Photochemical Activities of N-Nitroso Carboxamides and Sulfoximides as well as Their Application to DNA Cleavage,” Cover Article; Chem.--Eur. J. 2009, 15, 8742–8750.
  4. Tsai, T.-L.; Shieh, D.-B.; Yeh, C.-S.; Tzeng, Y.-H.; Hete, K.; Chuang, K.-S.; Hwu, J. R.; Su, W.-C. “The Down Regulation of Target Genes by Photo Activated DNA Nanoscissors,” Biomaterials 2010, 31, 6545–6554.
  5. Hwu, J. R.; Lin, S.-Y.; Tsay, S.-C.; De Clercq, E.; Leyssen, P.; Neyts, J. “Coumarin–Purine Ribofuranoside Conjugates as New Agents Against Hepatitis C Virus,” J. Med. Chem. 2011, 54, 2114–2126.
  6. Hwu, J. R.; Chang Hsu, Y. "Stereospecific Benzyne-Induced Olefination from -Amino Alcohols and Its Application to the Total Synthesis of (–)-1-Deoxy-D-fructose," Chem.--Eur. J. 2011, 17, 4727–4731.
  7. Chang Hsu, Y.; Hwu, J. R. “Deoxygenative Olefination Reaction as the Key Step in the Syntheses of Deoxy and Iminosugars,” Chem.--Eur. J. 2012, 18, 7686–7690.
  8. Hwu, J. R.; Swain, S. P. “Silicon-Induced Phenanthrene Formation from Benzynes and Allenylsilanes,” selected as Highlights in Current Synthetic Organic Chemistry by SYNFACTS, Thieme; Chem.--Eur. J. 2013, 19, 6556–6560.
  9. Hwu, J. R.; Kapoor, M.; Li, R.-Y.; Lin, Y.-C.; Horng, J.-C.; Tsay, S.-C. “Synthesis of Nucleobase Functionalized Carbon Nanotubes and Their Hybridization with Single-stranded DNA,” Cover Article; Chem. -- Asian J. 2014, 9, 3408–3412.

 

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