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Tan, Kui-Thong -2

Title： Assistant Professor
Education： Max-Planck Institute,Dortmund(Germany)(Ph.D) (2007)
National University of Singapore(Singapore(B.S.) (2001)
Office： Chemistry Building R724
Phone number： 35665
E-mail： kttn@mx.nthu.edu.tw
Web site： http://my.nthu.edu.tw/~chem/faculty/e-Tankui_web/e-Tankui.html

Work Experience：

2011 ~
2007 ~ 2011
Assistant Professor of NTHU
Postdoctoral Research：Swiss Federal Institute of Technology, Lausanne, Switzerland

Research Areas：

Organic Chemistry, Analytical Chemistry, Chemical Biology


Journal Articles：
  1. K.-T. Tan, M. A. Brun, K. Johnsson. Semisynthetic Fluorescent Biosensors for Intracellular Sensing: Real-Time Tracking of Uptake and Clearance of Unmodified Sulfonamide Drugs in Living Cells. Submitted for Publication.
     
  2. Y.-W. Wu, L. K. Oesterlin, K-T. Tan, H. Waldmann, K. Alexandrov, R. S. Goody. MembraneTargeting Mechanism of RabGTPases Elucidated by Semisynthetic Protein Probes. Nat. Chem. Biol. 2010, 6, 534-540 (impact factor: 16.08)
     
  3. A. Gautier, E. Nakata, G. Lukinavičius, K.-T. Tan, K. Johnsson. Selective Crosslinking of Interacting Proteins using Self-Labeling Tags. Accepted for Publication in J. Am. Chem. Soc.2009, 131, 17954-17962. (impact factor: 8.1)
     
  4. K.-T. Tan, E. Guiu-Rozas, R. S. Bon, Z. Guo, C. Delon, S. Wetzel, S. Arndt, K. Alexandrov, H. Waldmann, R. S. Goody, Y.-W. Wu, W. Blankenfeldt. Design, Synthesis and Characterization of Peptide-Based RabGGTase Inhibitors. J. Med. Chem. 2009, 52, 8025-8037. (impact factor: 4.9)
     
  5. M. A. Brun, K.-T. Tan, E. Nakata, M. J. Hinner, K. Johnsson.Semisynthetic Fluorescent Sensor Proteins Based on Self-Labeling Protein Tags. J. Am. Chem. Soc. 2009, 131, 4873-5884. (Times cited: 4,impact factor: 8.1)
     
  6. Z. Guo, Y. W. Wu, K.-T. Tan, R. S. Bon, E. Guiu-Rozas, C. Delon, U. T. Nguyen, S. Wetzel, S. Arndt, R. S. Goody, W. Blankenfeldt, K. Alexandrov, H. Waldmann. Development of Selective RabGGTase Inhibitors and Crystal Structure of a RabGGTase-Inhibitor Complex. Angew. Chem., Int. Ed. Engl. 2008, 47, 3747-3750. (Times cited: 3, impact factor: 10.8)
     
  7. A. Vogel, K.-T. Tan, H. Waldmann, S. E. Feller, M. F. Brown, D. Huster. Flexibility of Ras Lipid Modifications Studied by 2H Solid-State NMR and Molecular Dynamics Simulations. Biophys. J.2007, 93, 2697-2712. (Times cited: 9, impact factor: 4.6)
     
  8. Y.-W. Wu, K.-T. Tan, H. Waldmann, R. S. Goody, K. Alexandrov. Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators Proc. Natl. Acad. Sci. U.S. A. 2007, 104, 12294-12299. (Times cited: 11, Impact factor: 9.3)
     
  9. G. Reuther, K.-T. Tan, A. Vogel, C. Nowak, K. Arnold, J. Kuhlmann, H. Waldmann, D. Huster.The Lipidated Membrane Anchor of Full Length N-Ras Protein Shows an Extensive Dynamics as Revealed by Solid-State NMR Spectroscopy. J. Am. Chem. Soc. 2006, 128, 13840-13846. (Times cited: 21, impact factor: 8.1)
     
  10. G. Reuther, K.-T. Tan, J. Köhler, C. Nowak, A. Pampel, K. Arnold, J. Kuhlmann, H. Waldmann, D. Huster. Molecular Dynamics of a Membrane Bound Lipid-Modified Human N-Ras   Protein Determined by Solid-State NMR Spectroscopy. Angew. Chem., Int. Ed. Engl. 2006, 45,5387-5390 (Times cited: 17, impact factor: 10.8)
     
  11. Y. C. Teo, K.-T. Tan, T. P. Loh. Catalytic Asymmetric Allylation of Aldehydes via a Chiral Indium(III) Complex. Chem. Commun., 2005, 1318-1320. (Times cited: 40, impact factor: 5.3)
     
  12. C. L. K. Lee, C. H. A. Lee, K.-T. Tan, T. P. Loh. An Unusual Approach to the Synthesis of Enantiomerically Cis Linear Homoallylic Alcohols Based on the Steric Interaction Mechanism of Camphor Scaffold.  Org. Lett. 2004, 6, 1281-1283. (Times cited: 28, impact factor: 5.1)
     
  13. K.-T. Tan, S. S. Chng, H. S. Cheng, T. P. Loh. Development of General a-Regioselective Metal-mediated Allylation Reactions in Aqueous Media and a New Mechanistic Proposal for the Origin of a-Regioselectivity. J. Am. Chem. Soc. 2003, 125, 2958-2963. (Times cited: 69, impact factor: 8.1)
     
  14. T. P. Loh, C. L. K. Lee, K.-T. Tan.The First Example of Enantioselective Allyl Transfer from a Linear Homoallylic Alcohol to an Aldehyde. Org. Lett. 2002, 4, 2985-2987. (Times Cited: 21, impact factor: 5.1)
     
  15. T. P. Loh, Q. Y. Hu, Y. K. Chok, K.- T. Tan. Homoallylic sterol/indium (III) Lewis acid: Novel Enantioselective Allylation Reagent System Exhibiting a-regioselectivity. Tet. Lett. 2001, 42, 9277-9280. (Times Cited: 27, impact factor: 2.5)
     
  16. T. P. Loh, K.-T. Tan,Q. Y. Hu. A New Mechanistic Proposal for the Origin of a-Homoallylic Alcohols in Indium-Mediated Allylation Reaction in Water. Tet. Lett. 2001, 42, 8705-8708. (Times Cited: 30, impact factor: 2.5)
     
  17. T. P. Loh, K.-T. Tan, J. Y. Yang, C. L. Xiang. Development of a Highly a-Regioselective Indium-Mediated Allylation Reaction in Water. Tet. Lett. 2001, 42, 8701-8703. (Times Cited: 28, impact factor: 2.5)
     
  18. T. P. Loh, K.-T. Tan, Q. Y. Hu. The first In(OTf)3 catalyzed conversion of kinetically formed homoallylic alcohols into the thermodynamically preferred regioisomers: Application to the synthesis of 22 a-sterols. . 2001, 40, 2921-2922. (Times Cited: 41, impact factor: 10.8)
     
  19. T. P. Loh, Q. Y. Hu, K.-T. Tan, H. S. Cheng. Diverse cyclization catalyzed by In(OTf)3 fro the convergent assembly of substituted tetrahydrofurans and tetrahydropyrans. Org. Lett. 2001,3, 2669-2672. (Times Cited: 40, impact factor: 5.1)

 

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