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Hwu, Jih-Ru(Reuben) -2

Title： Professor

Education：

Stanford University(USA)(Ph.D.) (1982)
National Tsing Hua University(B.S.) (1976)
Office： Chemistry Building R602
Phone number： 33412
E-mail： jrhwu@mx.nthu.edu.tw
Web site： http://my.nthu.edu.tw/~chem/faculty/e-jrhwu_web/e-jrhwuweb.html

Work Experience：

1991 ~
1982 ~ 1991
Professor of NTHU
Associate Professor of The Johns Hopkins University

Research Areas：

Bionano Sciences & Technology, Gene Therapy, Organic Synthesis and Reactions,
Silicon Chemistry, Polymer Science


Journal Articles：
  1. Hu, K.-W.; Huang, C.-C.; Hwu, J. R.; Su, W.-C.; Shieh, D.-B.; Yeh, C.-S. “A New Photothermal Therapeutic Agent: Core-Free Nanostructured AuxAg1-x Dendrites," Chem.--Eur. J. 2008, 14, 2956–2964.
     
  2. Hwu, J. R.; Yang, J.-R.; Tsay, S.-C.; Hsu, M.-H.; Chen, Y.-C.; Chou, S.-S. P “Photo-induced DNA Cleavage by (Heterocyclo)carbonyl Oxime Esters of Anthraquinone,” Tetrahedron Lett.2008, 49, 3312–3315.
     
  3. Huang, C.-C.; Lo, Y.-W.; Kuo, W.-S.; Hwu, J. R.; Su, W.-C.; Shieh, D.-B.; Yeh, C.-S. “Facile Preparation of Self-Assembled Hydrogel-like GdPO4.H2O Nanorods,” Langmuir 2008, 24, 8309–8313.
     
  4. Hwu, J. R.; Hsu, M.-H.; Huang, R. C. H. “New Nordihydroguaiaretic Acid Derivatives as Anti-HIV Agents,” Bioorg. Med. Chem. Lett. 2008, 18, 1884–1888.
     
  5. Hwu, J. R.; Singha, R.; Hong, S. C.; Chang, Y. H.; Das, A. R.; Vliegen, I.; De Clercq, E.; Neyts, J. “Synthesis of New Benzimidazole–Coumarin Conjugates as Anti-Hepatitis C Virus Agents,” Antiviral Res. 2008, 77, 157–162.
     
  6. Hsin, Y.-L.; Lin, C.-F.; Liang, Y.-C.; Hwang, K. C.; Horng, J.-C,; Ho, J.-a. A.; Lin, C.-C.; Hwu, J. R. “Microwave Arcing Induced Formation and Growth Mechanisms of Core-shell Metal/carbon nanoparticles in Organic Solutions,” cover article, Adv. Funct. Mater. 2008, 18, 1–9.
     
  7. Hwu, J. R.; Chen, C. H.; Hsu, C.-I.; Das, A. R.; Li, Y. C.; Lin, L. C. “Silicon-Induced Ene-Type Reaction in the Thermal Conversion of Enolates to b-Silyl Enones with Molecular Dioxygen,” Org. Lett. 2008, 10, 1913–1916.
     
  8. Hsu, M.-H.; Josephrajan, T.; Yeh, C.-S.; Shieh, D.-B.; Su, W.-C.; Hwu, J. R. "Novel Arylhydrazone-Conjugated Gold Nanoparticles with DNA-Cleaving Ability: The First DNA-Nicking Nanomaterial," Bioconjugate Chem. 2007, 18, 1709–1712.
     
  9. Hwu, J. R. "Magic Nano Biomaterials as Photo-induced DNA-Cleaving Agents," Drug. Future 2007, 32, Suppl. A, 32–33.
     
  10. Pu, Y.-C., Hwu, J. R.; Su, W.-C.; Shieh, D.-B.; Tzeng, Y; Yeh, C.-S. "Water Dissolvable Sodium Sulfate Nanowires as a Versatile Template for the Fabrication of Polyelectrolyte and Metal-Based Nanotubes," J. Am. Chem. Soc. 2006, 128, 11606–11611.
     
  11. Hwu, J. R.; Lin, C.-F.; Tsay, S.-C. "Hexamethyldisilathiane in Novel Chemical Transformation: Concept of Counterattack Reagent," Phosphorus, Sulfur, Silicon, Relat. Elem. 2005, 180, 1389–1393.
     
  12. Lee, F.-Y.; Huang, J.-J.; Chen, Y.-J.; Lin, K.-J.; Lee, G.-H.; Peng, S.-M.; Hwu, J. R.; Lu, K.-L. "Os(CO)2(2-SC5H4N(O))(2-SC5H4N): Structural Evidence for the Transformation of Pyridine-2-thione N-Oxide to Pyridine-2-thiolate in Osmium Complexes," J. Organomet. Chem. 2005, 690, 441–449.
     
  13. Hwu, J. R.; King, K. Y. "Design, Synthesis, and Photo-degradation of New Silicon-containing Polyureas," Cover Article; Chem.--Eur. J. 2005, 11, 3805–3815.
     
  14. Hwu, J. R.; Chuang, K.-S.; Chuang, S. H.; Tsay, S.-C. "New Benzo[b]furans as Electroluminescent Materials for Emitting Blue Light," Org. Lett. 2005, 7, 1545–1548.
     
  15. Dohm, J. A.; Hsu, M.-H.; Hwu, J. R.; Huang, R. C. C.; Moudrianakis, E. N.; Lattman, E. E.; Gittis, A. G. "Influence of Ions, Hydration, and the Transcriptional Inhibitor P4N on the Conformations of the Sp1 Binding Site: Three Different Conformations of the Sp1 Binding Site," J. Mol. Biol. 2005, 349, 731–744.
     
  16. Hwu, J. R.; Josephrajan, T.; Tsay, S.-C. "Silicon-Catalyzed Conversion of Nitro Compounds to Ketones and Poly(1,3-diketones)," Synthesis 2006, 3305–3308.
     
  17. Hwu, J. R.; Wong, F. F. "Sodium Bis(trimethylsilyl)amide in the Oxidative Conversion of Aldehydes to Nitriles," Eur. J. Org. Chem. 2006, 2513–2516.
     
  18. Hwu, J. R.; Das, A. R.; Yang, C. W.; Huang, J.-J.; Hsu, M.-H. "1,2-Elimination in Novel Reductive Coupling of Nitroarenes to Give Azoxy Arenes by Sodium Bis(trimethylsilyl)amide," Org. Lett. 2005, 7, 3211–3214.
     
  19. Shieh, D. B.; Su, C.-H.; Chang, F.-Y.; Wu, Y.-N.; Su, W.-C.; Hwu, J. R.; Chen, J.-H.; Yeh, C.-S. “Aqueous Nickel-Nitrilotriacetate Modified Fe3O4–NH3+ Nanoparticles for Protein Purification and Cell Targeting,” Nanotechnology 2006, 17, 4174–4182.
     
  20. Huang, C.-C.; Hwu, J. R.; Su, W.-C.; Shieh, D.-B.; Tzeng, Y.; Yeh, C.-S. “Surfactant-Assisted Hollowing of Cu Nanopartilces Involving Halide-Induced Corrosion–Oxidation Processes,” Chem.--Eur. J. 2006, 12, 3805–3810.
     
  21. Hwu, J. R.; Chen, J. H.; King, K. Y. "-Silyl Carbonyl Groups as New Photo-degradation Units in Poly(butadienes)," Macromolecules 2004, 37, 3968¬–3969.
     
  22. Hwu, J. R.; Hsu, C.-Y.; Jain, M. L. "Efficient Photolytic Esterification of Carboxylic Acids with Alcohols in Perhalogenated Methane," Tetrahedron Lett. 2004, 45, 5151–5154.
     
  23. Hwu, J. R.; Lin, C. C.; Chuang, S. H.; King, K. Y.; Su, T.-R.; Tsay, S.-C. "Aminyl and Iminyl Radicals from Arylhydrazones in the Photo-induced DNA Cleavage," Bioorg. Med. Chem. 2004, 12 , 2509–2515.
     
  24. Hwu, J. R.; Sambaiah, T.; Chakrabortya, S. K. "New Transformations of 2-Nitro-2,3-dihydrofurans to Multi-functionalized Dihydrofurans," Tetrahedron Lett. 2003, 44, 3167–3169.(SCI)
     
  25. Hwu, J. R.; Tsay, S.-C.; Hong, S. C.; Leu, Y.-J.; Liu, C.-F.; Chou, S.-S. P. "Oxime Esters of Anthraquinone as Photo-induced DNA-Cleaving Agents for Single- and Double-strand Scissions," Tetrahedron Lett. 2003, 44, 2957–2960.(SCI)
     
  26. Cabeza, J. A.; del Río, I.; Riera, V.; Suárez, M.; Álvarez-Rúa, C.; García–Granda, S.; Chuang, S.-H.; Hwu, J. R. "Di- and Trinuclear Ruthenium and Osmium Bis(2-pyridyl) Ketone Oximate Derivatives," Eur. J. Inorg. Chem. 2003, 2003, 4159–4165.(SCI)
     
  27. Hwu, J. R.; Chen, B.-L.; Lin, C.-F.; Murr, B. L. "Electronic and Steric Effects of Silyl Groups in Silicon-Directed Norrish Type Cleavages," invited article, J. Organomet. Chem. 2003, 686, 198–201.(SCI)
     
  28. Hwu, J. R.; King, K. Y. "Calcium in Organic Synthesis" In Main Group Metals in Organic Synthesis; Yamamoto, H.; Oshima, K., Eds.; Wiley–VCH, Weinheim, 2004; Vol. 1, Chapter 4.
     
  29. Hwu, J. R.; Ethiraj, K. S.; Hakimelahi, G. H. "Biological Activity of Some Monocyclic- and Bicyclic -Lactams with Specified Functional Groups," Mini-Rev. Med. Chem. 2003, 3, 305–313.(NOT SCI)
     
  30. Huang, R. C. C.; Li, Y.; Giza, P. E.; Gnabre, J. N.; Abd-Elazem, I. S.; King, K. Y.; Hwu, J. R. "Antiviral Agent Tetraglycylated Nordihydroguaiaretic Acid Hydrochloride as a Host-Dependent Viral Inhibitor," Antiviral Res. 2003, 58, 57–64.(SCI)
     
  31. Hwu, J. R.; Ethiraj, K. S. "Disilane" In Science of Synthesis; Organometallics: Compounds of Group 15 (As, Sb, Bi) and Silicon Compounds; Fleming, I., Ed.; Georg Thieme Verlag: New York, 2002; Category 1, Vol. 4, Chapter 4.4.5.(NOT SCI)
     
  32. Hakimelahi, G. H.; Gassanov, G. S., Hsu, M.-H.; Hwu, J. R.; Hakimelahi, S. "A Novel Approach Towards Studying Non-Genotoxic Enediynes as Potential Anticancer Therapeutics," Bioorg. Med. Chem. 2002, 10, 1321–1328.(SCI)
     
  33. Hakimelahi, G. H.; Gassanov, G. S., Hsu, M.-H.; Hwu, J. R.; Hakimelahi, S. "A Novel Approach Towards Studying Non-Genotoxic Enediynes as Potential Anticancer Therapeutics," Bioorg. Med. Chem. 2002, 10, 1321–1328.(SCI)
     
  34. Hwu, J. R.; Lu, K.-L.; Yu, S.-F.; Yu, L.-J.; Kumaresan, S.; Lin, K.-J.; Tsay, S.-C. "New Triruthenium Clusters as Photo-Induced DNA Binding and Cleaving Agents," Photochem. Photobiol. 2002, 75, 457–461.(SCI)
     
  35. Hwu, J. R.; Lu, K.-L.; Yu, S.-F.; Yu, L.-J.; Kumaresan, S.; Lin, K.-J.; Tsay, S.-C. "New Triruthenium Clusters as Photo-Induced DNA Binding and Cleaving Agents," Photochem. Photobiol. 2002, 75, 457–461.(SCI)
     
  36. King, K. Y.; Hakimelahi, G. H.; Huang, R. C.; Hwu, J. R. "Design, Synthesis, and Binding Studies of Highly Water Soluable Nordihydroguaiaretic Acid Derivatives," J. Genetics. Mol. Biol. 2002, 13, 248–257.(NOT SCI)
     
  37. Hwu, J. R.; Jain, M. L.;Tsai, F.-Y.; Balakumar, A.; Hakimelahi, G. H.; Tsay, S.-C. "Ceric Ammonium Nitrate Impregnated on Silica Gel in the Removal of the tert-Butoxycarbonyl Group," ARKIVOC 2002, 9, 28–36.(NOT SCI)
     
  38. Huang, R. C. C.; Heller, J. D.; Hwu, J. R.; King, K. Y. "Nordihydroguaiaretic Derivatives for Use in Treatment of Tumors," U.S. Patent 6 417 234 B1, 2002.
     
  39. Sambaiah, T.; King, K.-Y.; Tsay, S.-C.; Mei, N.-W.; Lai, Y.-K.; Lieu, C.-H.; Hwu, J. R. "Synthesis and Immunofluorescence Assay of a New Biotinylated Paclitaxel," Eur. J. Med. Chem. 2002, 37, 349–353.(SCI)
     
  40. Licandro, E.; Maiorana, S.; Capella, L.; Manzotti, R.; Papagni, A.; Vandoni, B.; Albinati, A.; Chuang, S. H.; Hwu, J. R. "Michael Addition of Chiral Fishcher Aminocarbene Complexes to Nitroolefins; Study on the Effect of the Michael Acceptor Structure on Diastereoselectivity," Organometallics 2001, 20, 485-496.(SCI)
     
  41. Hwu, J. R.; Tsay, S.-C.; Sambaiah, T.; Lai, Y.-K.; Lieu, C.-H.; Hakimelahi, G. H.; King, J. Y. "Design and Synthesis of Paclitaxel-Containing Aminoester Phosphate and Phosphoamidate," Mendeleev Commun. 2001, 11, 216-217.(SCI)
     
  42. Hwu, J. |R.; Tsai, f. Y.; Tsay, S. C.; Chuang, S. H.; Su, T. R.; Lin, S. B.; Lin, W. C.; Hsieh, C. L.; Lan, L. S. "Interaction Between 3-(p-Tolylamino)-1,5-azulenequinone and the Deoxyguanosine Residue in Various Oligonucleotides Upon Photolysis," Photochem. Photobiol.2001, 74, 689-693.(SCI)
     
  43. Hwu, J. R.; King, K. Y. "Versatile Reagent Ceric Ammonium Nitrate in Modern Chemical Synthesis," Curr. Sci. 2001, 81, 1043-1053.(NOT SCI)
     
  44. Hakimelahi, G. H.; Mei, N. W.; Moosavi-Movahedi, A. A.; Davari, H.; Hakimelahi, S.; King, K. Y.; Hwu, J. R.; Wen, Y. S. "Synthesis and Biological Evaluation of Purine-Containing Butenolides," J. Med. Chem. 2001, 44, 1749-1757.(SCI)
     
  45. Hwu, J. R.; Sambaiah, T.; Liao, J. H.; Chen, K. L.; Wen, Y. S. "Novel Transformations of -Silyl Nitro Compounds," Org. Lett. 2001, 3, 4267-4269.(SCI)
     
  46. Hwu, J. R.; Tsay, S.-C.; Lin, L. C.; Chueh, L. L. "-Silylcycloalkanone Enol Acetates by Electrochemical Method," J. Am. Chem. Soc. 2001, 123, 5104-5105.(SCI)
     
  47. Hakimelahi, G. H.; Jain, M. L.; Ly, T. W.; Chen, I-C.; Ethiraj, K. S.; Hwu, J. R.; Moshfegh, A. A. "Self-Sensitized Photooxygenation of 3,4-Dialkoxyfurans to Vitamin C or Its Derivatives," J. Org. Chem. 2001, 66, 7067-7071.(SCI)
     
  48. Tsai, F. Y.; Lin, S. B.; Tsay, S. C.; Lin, W. C.; Hsieh, C. L.; Chuang, S. H.; Kan, L. S.; Hwu, J. R. "Photochemical Cleavage of Single- and Double-Stranded Oligonucleotides by 3-(p-Tolylamino)-1,5-azulenequinone," Tetrahedron Lett., 2001, 42, 5733-5735.(SCI)

Patent：
  1. Hwu, J. R.; Tsay, S. C.; Lu, K. L.; Huang, J. J.; Hung, J. T.; Yu, S. F. “Organometallic complex,” Germany Patent DE60219621D, 2007.
     
  2. Huang, R. C. C.; Heller, J. D.; Hwu, J. R.; King, K. Y.; Hakimelahi, G. H. “Nordihydroguaiaretic derivatives for use in treatment of tumors,” H.K. Patent HK1050860, 2007.
     
  3. Hwu, J. R.; Tsay, S. C.; Chuang, K. S. “Novel benzo[b]furan derivatives and their use,” U.S. Patent US 2007152569, 2007.
     
  4. Chang, C.-C.; Huang, R. C. C.; Lee, Y. C.; Hsu, M.-H.; Hwu, J. R.; Mold, D. E. “Use Of Nordihydroguaiaretic Acid Derivatives In The Treatment Of Drug Resistant Cancer, Viral And Microbial Infection,” Canda Patent CA2583336 2006.
     
  5. Hwu, J. R.; Magendran, B,; Chakraborty, S. K.; Das, A. R.; Tsay, S. C.; Sheu, K. W.; Shu, C. M.; Lu, C. K.; Chang, W. M. “Process for preparation of tamsulosin and its derivatives,” Europe Patent EP1734036, 2006.
     
  6. Hwu, J. R.; Tsay, S. C. “Anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use,” U.S. Patent US2006246148, 2006.
     
  7. Hwu, J. R.; Tsay, S.-C. "Anti-Bacterial, Anti-Viral, and Anti-Fungus Composition, Its Preparationa nd Use," Republic of China Patent, I 228051, 2005.
     
  8. Huang, R. C. C.; Heller, J. D.; Hwu, J. R.; King, K. Y. "Nordihydroguaiaretic Derivatives for Use in Treatment of Tumors," U.S. Patent 0 065 016 A1, 2003
     
  9. Hwu, J. R.; Tsay, S.-C.; Hakimelahi, S. "Syntheses of New Isodethiaazacephems and Isodethiaazacephams, and Use as Potent Antibacterial Agents," U.S. Patent 6 348 454, 2002.
     
  10. Lu, K.-L.; Huang, J.-J.; Yu, S.-F.; Hung, J.-T.; Hwu, J. R.; Tsay, S.-C.; "Organometallic Complex," U.S. Patent US 6,458,833 B1, 2002.
     
  11. Hwu, J. R.; Tsay, S.-C.; Hakimelahi, G. H.; Lin, C. C.; Tseng, W. N.; Moshfegh, A. A.; Azaripour, A.; Mottaghian, H. "Phloroglucidic Acid and Derivatives as Antibacterial Agents," U.S. Patent 6 288 265 B1, 2001.

 

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