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Department of Chemistry
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Sheng-Kai Wang

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Education

PhD, The Scripps Research Institute (2008)
BS, National Tsing Hua University (1999)

 

Professional Experience
2019 ~  Associate Professor of NTHU
2013 ~ 2019 Assistant Professor of NTHU
2008 ~ 2013 Postdoctoral Research, The Scripps Research Institute
2001 ~ 2002 Research Assistant, Academia Sinica
2000 ~ 2001 Military Service

Research Interest

Carbohydrate Chemistry, Bioorganic Chemistry, Chemical Biology

Publications
  1. Comprehensive characterization of polyproline tri-helix macrocyclic nanoscaffolds for predictive ligand positioning. Tsai C. L., Chang J. W., Cheng, K. Y., Lan Y. J., Hsu Y. C., Lin Q. D., Chen T. Y., Shih O., Lin C. H., Chiang P. H., Simenas M., Kalendra V., Chiang Y. W.*, Chen C.*, Jeng U. S.*, Wang S. K.* Nanoscale Adv. 2023, accepted.
  2. Design and synthesis of fluorinated peptides for analysis of fluorous effects on the interconversion of polyproline helices. Li M. C., Liu Y. J., Hsu K. C., Lin T. H., Lin C. W., Horng J. C., Wang S. K.* Bioorg Chem. 2022, 119, 105491.
  3. Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation. Lee W. H., Chen X., Liu I. J., Lee J. H., Hu C. M., Wu H. C., Wang S. K., Lee W. H.*, Ma C.* Cell Rep. 2022, 41, 111555.
  4. Tsai CL, Wu SY, Hsu HK, Huang SB, Lin CH, Chan YT,* Wang SK*. Preparation and conformational analysis of polyproline tri-helix macrocycle nanoscaffolds of varied sizes. Nanoscale 2021, 13, 4592-4601.
  5. Pawar S, Hsu L, Narendar Reddy T, Ravinder M, Ren CT, Lin YW, Cheng YY, Lin TW, Hsu TL, Wang SK, Wong CH, Wu CY*. Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation. ACS Chem Biol. 2020, 15, 2382-2394.
  6. Wen HC, Lin CH, Huang JS, Tsai CL, Chen TF, Wang SK*. Selective targeting of DC-SIGN by controlling the oligomannose pattern on a polyproline tetra-helix macrocycle scaffold. Chem Commun. 2019, 55, 9124-9127.
  7. Lin CH, Wen HC, Chiang CC, Huang JS, Chen Y, Wang SK* Polyproline Tri-Helix Macrocycles as Nanosized Scaffolds to Control Ligand Patterns for Selective Protein Oligomer Interactions. Small. 2019, 15, e1900561.
  8. Tseng WH, Li MC, Horng JC, Wang SK* Strategy and Effects of Polyproline Peptide Stapling by Copper(I)-Catalyzed Alkyne-Azide Cycloaddition Reaction. ChemBioChem. 2019, 20, 153-158.
  9. Huang KW, Lai YT, Chern GJ, Huang SF, Tsai CL, Sung YC, Chiang CC, Hwang PB, Ho TL, Huang RL, Shiue TY, Chen Y*, Wang SK*  Galactose Derivative-Modified Nanoparticles for Efficient siRNA Delivery to Hepatocellular Carcinoma. Biomacromolecules. 2018, 19, 2330-2339.
  10. Huang SF, Lin CH, Lai YT, Tsai CL, Cheng TR, Wang SK* Development of Pseudomonas aeruginosa Lectin LecA Inhibitor by using Bivalent Galactosides Supported on Polyproline Peptide Scaffolds. Chem Asian J. 2018, 13, 686-700.
  11. Liu CH, Chern GG, Hsu FF, Huang KW, Sung YC, Huang HC, Qiu JT, Wang SK, Lin CC, Wu CH, Wu HC, Liu JY, Chen Y.* A multifunctional nanocarrier for efficient TRAIL-based gene therapy against hepatocellular carcinoma with desmoplasia. Hepatology. 2018, 67, 899-913.
  12. Lin TH, Lin CH, Liu YJ, Huang CY, Lin YC, Wang SK* Controlling Ligand Spacing on Surface: Polyproline-Based Fluorous Microarray as a Tool in Spatial Specificity Analysis and Inhibitor Development for Carbohydrate-Protein Interactions. ACS Appl Mater Interfaces. 2017, 9, 41691-41699.
  13. Wang SK,* Cheng CM.* Glycan-based diagnostic devices: current progress, challenges and perspectives. Chem Commun 2015, 51, 16750-16762.
  14. Doores KJ, Huber M, Le K, Wang SK, Doyle-Cooper C, Cooper A, Pantophlet R, Wong CH, Nemazee D, and Burton DR. 2G12-expressing B cell lines inform HIV carbohydrate vaccine design strategies. J Virol 2013, 87, 2234-2241.
  15. Al-Shareffi E, Chaubard JL, Leonhard-Melief C, Wang SK, Wong CH, Haltiwanger RS. 6-Alkynyl fucose is a bioorthogonal analogue for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2. Glycobiology 2013, 23, 188-198.
  16. Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR, Wilson IA. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science 2011, 334, 1097-1103
  17. Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien JP, Wang SK, Chan-Hui PY, Hammond PW, Olsen OA, Ramos A, Phung P, Wrin T, Simek MD, Fling S, Wong CH, Phogat S, Koff WC, Wilson IA, Burton DR, Poignard P. Redefining potency and breadth in antibody neutralization of HIV. Nature 2011, 477, 466-470.
  18. Liang CH,† Wang SK† (equal contribution), Lin CW, Wang CC, Wong CH, Wu CY, Effects of neighboring glycans on antibody-carbohydrate interaction. Angew Chem Int Ed. 2011, 50, 1608-1612.
  19. Astronomo RD, Kaltgrad E, Udit AK, Wang SK, Doores KJ, Huang CY, Pantophlet R, Paulson JC, Wong CH, Finn MG, Burton DR. Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds. Chem Biol. 2010, 17, 357-370.
  20. Wang SK, Liang PH, Astronomo RD, Hsu TL, Hsieh SL, Burton DR, Wong CH. Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN. Proc Natl Acad Sci USA 2008, 105, 3690-3695.
  21. Liang PH, Wang SK, Wong CH. Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants. J Am Chem Soc. 2007, 129, 11177-11184.
  22. Hsu TL, Hanson SR, Kishikawa K, Wang SK, Sawa M, Wong CH. Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells. Proc Natl Acad Sci USA. 2007, 104, 2614-2619.
  23. Sanna MG†, Wang SK† (equal contribution), Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol 2006, 2, 434-441.
  24. Wu CY, Brik A, Wang SK, Chen YH, Wong CH. Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ. ChemBioChem 2005, 6, 2176-2180.
  25. Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol 2005, 6, 1228-1235.
  26. Liang FS, Wang SK, Nakatani T, Wong CH. Targeting RNAs with tobramycin analogues. Angew Chem Int Ed 2004, 43, 6496-6500.
  27. Pratap RP, Chu CY, Hwang, DR, Wang SK, Uang BJ. Recent advances in the oxovanadium mediated biaryl coupling and modified Mannich-type reactions. Coordin Chem Rev 2003, 237, 257-269.
  28. Chu CY, Hwang DR, Wang SK, Uang BJ. Chiral oxovanadium complex catalyzed enantioselective oxidative coupling of 2-naphthols. Chem Comm 2001, 980-981.
  29. Hwang DR, Chu CY, Wang SK, Uang BJ. Aerobic oxidation of hydroquinones to quinones catalyzed by VO(acac)2. Synlett 1999, 77-78.

 

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